Musculoskeletal Care

• UC-II® (undenatured type II collagen, 40 mg) — oral undenatured type II collagen is thought to act by oral tolerance: small amounts of native type II collagen presented to gut-associated lymphoid tissue induce regulatory T-cells that down-regulate immune responses against joint cartilage, reducing inflammation and pain and improving function. Clinical trials commonly use 40 mg/day.

• Curcumin (Curcumin C3 Complex®, 100 mg) — curcuminoids inhibit multiple pro-inflammatory signalling pathways (NF-κB, COX/LOX modulation, cytokine down-regulation) and provide antioxidant effects; bioavailability of curcumin is limited unless formulated (e.g., C3 Complex®, nanoparticles, or combined with piperine). Clinical evidence supports symptom improvement in OA with curcumin formulations.

• Boswellin® Super (Boswellia serrata, 100 mg) — standardized boswellic acid extracts (notably AKBA) inhibit 5-lipoxygenase and reduce leukotriene-mediated inflammation; clinical studies of Boswellin® Super show improvements in pain and function in OA.

• Hyaluronic acid (oral, 80 mg) — oral HA is proposed to contribute to joint lubrication and viscoelasticity indirectly (systemic absorption of low-molecular-weight fractions) and has shown benefits for knee pain in multiple trials and reviews.

• BioPerine® (piperine, 2.5 mg) — increases intestinal absorption and systemic bioavailability of curcuminoids (and other drugs/nutrients) by inhibiting certain drug-metabolising enzymes and intestinal efflux; small piperine doses are commonly used to boost curcumin levels. Note: piperine can also potentiate drug interactions.

• Keep out of reach of children.
• Do not exceed the stated recommended daily dose.
• This product is a nutritional supplement and should not be used as a substitute for a varied diet or prescribed medication.
• Consult a healthcare professional before use if you have a pre-existing medical condition (e.g., liver, kidney, or heart disease) or are undergoing treatment.
• Source warnings: UC-II is derived from chicken sternum cartilage — mention for patients with food-related allergies or vegetarians/vegans.

• Hypersensitivity/Allergy: Do not take if allergic to any component (UC-II contains chicken sternal cartilage; Curcumin and Bioperine are from botanical sources).
• Gastrointestinal Distress: High doses of Curcumin and Boswellia can cause mild side effects like nausea, diarrhoea, or heartburn. Taking with food can help.
• Bleeding risk: curcumin and Boswellia may have mild antiplatelet effects; caution with anticoagulants/antiplatelet drugs (warfarin, aspirin, clopidogrel).
• Drug interaction risk via piperine: BioPerine® (piperine) can inhibit CYP enzymes and P-glycoprotein — it may raise blood levels of co-administered drugs (e.g., certain statins, antihypertensives, immunosuppressants, anticonvulsants). Use caution and check interactions.

• Known allergy or hypersensitivity to Undenatured Collagen Type II, Curcumin, Boswellia, Hyaluronic Acid, Piperine, or any excipients.
• May be contraindicated in individuals with known bleeding disorders or those on strong blood-thinning medication (due to potential mild antiplatelet effects of Curcumin/Boswellia).
• Paediatric use: not established — avoid in children unless directed by physician. (Label per local regulation.)

Drug Interaction 

• Anticoagulants/Antiplatelet Drugs (Blood Thinners): Curcumin and Boswellia may have mild antiplatelet effects. Use with caution if the patient is on drugs like Warfarin, Aspirin, or Clopidogrel, as it may increase the risk of bleeding.
• Medications metabolized by the liver (Cytochrome P450 substrates): Bioperine (Piperine) is a known inhibitor of certain liver enzymes (CYP450), which can increase the absorption and concentration of many concurrently administered drugs, potentially increasing their effects and side effects.
• Antidiabetic Drugs: Curcumin may lower blood sugar levels, potentially enhancing the effects of insulin or oral antidiabetic medications. Monitor blood glucose closely.
• Immunosuppressants: UC-II — immunomodulatory effects (oral tolerance) and Boswellia may affect the immune system's activity. Use with caution with immunosuppressant medications.

• Insufficient well-controlled human data. Most manufacturers advise avoiding high-dose curcumin and piperine in pregnancy; UC-II and Boswellia lack adequate safety data in pregnancy/lactation. Recommend avoid use during pregnancy and breastfeeding unless a physician advises otherwise.

Tendovia Tablet contains ingredients that synergistically support connective tissue regeneration and reduce inflammation:

• L-Arginine: Precursor of nitric oxide (NO); enhances microcirculation and nutrient delivery to tendons at the tendon–bone interface and supports collagen deposition during tendon healing and reducing oxidative stress.

• Collagen Peptide Type I: Supplies bioactive peptides (Pro-Hyp, Hyp-Gly) that stimulate fibroblasts and tenocytes to synthesize Type I collagen — the dominant protein in tendon matrix.

• Chondroitin Sulphate: Contributes structural glycosaminoglycans to extracellular matrix; protects collagen fibrils from enzymatic degradation; aids in tensile strength recovery.

• Vitamin C: Essential for collagen synthesis and acts as an antioxidant. It’s an essential co-factor for hydroxylation of proline/lysine in collagen maturation; accelerates tendon repair and reduces oxidative damage at the injury site.

• Hyaluronic acid (oral, 80 mg) — Improves tendon sheath lubrication, reduces friction, and modulates inflammatory cytokines. Promotes gliding and elasticity of tendons. 
• Curcumin (Curcumin C3 Complex®, 100 mg) — curcuminoids inhibit multiple pro-inflammatory signalling pathways (NF-κB, COX/LOX modulation, cytokine down-regulation) and provide antioxidant effects; bioavailability of curcumin is limited unless formulated (e.g., C3 Complex®, nanoparticles, or combined with piperine).
• Boswellin® Super (Boswellia serrata, 100 mg) — standardized boswellic acid extracts (notably AKBA) inhibit 5-lipoxygenase and reduce leukotriene-mediated inflammation and matrix metalloproteinase (MMP) activity in tendon tissue.
• BioPerine® (piperine, 2.5 mg) — increases intestinal absorption and systemic bioavailability of curcuminoids, and Boswellia actives (and other drugs/nutrients) by inhibiting certain drug-metabolising enzymes and intestinal efflux; small piperine doses are commonly used to boost curcumin levels. Note: piperine can also potentiate drug interactions.

• Lactation (Nursing Mothers): Safety is not established. Should be avoided unless specifically advised by a physician.