Neutraceuticals

• Ensure no co-existing iron overload disorders 
• Prolonged use should be monitored with serum iron, folate, B12, and zinc levels 
• Avoid taking with calcium or dairy (may reduce iron absorption) 

• Excess iron may lead to iron overload in susceptible individuals (e.g., hemochromatosis) 
• High-dose folic acid can mask B12 deficiency, so combination is appropriate 
• Zinc at high doses over time may lead to copper deficiency 

• Known hypersensitivity to any component 
• Conditions with iron overload (e.g., hemochromatosis, hemosiderosis) 
• Severe renal impairment (monitor zinc and B12 accumulation) 

• Iron absorption may be decreased by: Calcium, tetracyclines, quinolones 
• Zinc may interfere with absorption of: Tetracyclines, fluoroquinolones (space by 2 hours) 
• Vitamin B12 absorption can be reduced by: Proton pump inhibitors and metformin (long-term use) 
• Folic acid efficacy may be reduced by: Methotrexate, trimethoprim, sulfasalazine

• Safe and recommended during pregnancy and lactation 
• Supports foetal growth, neural tube development, and prevention of anemia

• Use with caution in individuals with a history of folate or B12 metabolism disorders. 
• Monitor homocysteine levels if used long-term for cardiovascular or neurological conditions. 

• High doses of B vitamins, especially B6, may cause peripheral neuropathy over prolonged use. 
• Monitor patients with renal impairment due to altered excretion of water-soluble vitamins. 
• Do not substitute for anti-epileptic or other prescribed medications. 

• Hypersensitivity to any component of the formulation 
• Leber’s disease (for Methylcobalamin) — may worsen optic nerve damage. 

• Anticonvulsants (e.g., phenytoin, phenobarbital) may decrease folate levels. 
• Chloramphenicol may interfere with the hematologic response to vitamin B12. 
• Methotrexate, sulfasalazine, and trimethoprim may reduce folate action. 
• Alcohol may impair absorption and metabolism of B-vitamins.

• Generally considered safe during pregnancy. 
• Folate is essential for neural tube development in fetuses. 
• Use under medical supervision.
  

• Monitor Vitamin B12 and folate levels periodically in long-term use. 
• Ensure correct diagnosis of neuropathy before starting supplementation.

• High doses of L-Carnitine may cause a fishy body odour in some individuals. 
• In rare cases, Methylcobalamin may unmask subclinical polycythemia or folate-deficiency-related symptoms. 
• Do not exceed recommended dose without medical supervision.

• Hypersensitivity to any of the active ingredients. 
• History of Leber's disease (hereditary optic nerve atrophy) – Methylcobalamin may aggravate the condition. 
• Folic acid should be used cautiously in individuals with untreated Vitamin B12 deficiency due to the risk of neurologic complications.
  

• L-Carnitine: May interact with warfarin (potentiation of anticoagulant effect). 
• Methylcobalamin: Absorption reduced by chronic use of proton pump inhibitors, H2 blockers, and metformin. 
• Folic Acid: May decrease serum phenytoin concentrations.
  

• Category A (Folic Acid, Vitamin B12): Safe when used at recommended doses. 
• L-Carnitine is generally considered safe, but high doses should be used only under medical supervision during pregnancy.
  

Hybrin Plus Tablet is a comprehensive neuro-nutritional formulation that helps maintain healthy nerve function, supports nerve regeneration, reduces oxidative stress, and corrects vitamin deficiencies associated with neuropathy.

Methylcobalamin (Vitamin B12): Essential for DNA synthesis, myelin sheath integrity, and nerve cell repair. It supports the regeneration of damaged neurons.

Folic Acid (Vitamin B9): Aids in DNA/RNA synthesis and repair, red blood cell formation, and works synergistically with B12 in neurological and haematological health.

Pyridoxine HCl (Vitamin B6): Involved in neurotransmitter production (serotonin, dopamine), protein metabolism, and immune function. Prevents B6 deficiency-related neuropathy.

Alpha Lipoic Acid (ALA): A potent antioxidant that regenerates other antioxidants (e.g., Vitamin C, E), improves glucose metabolism, and reduces oxidative stress in nerves.

Biotin (Vitamin B7): Supports energy metabolism, and is important for skin, hair, and nervous system function.

Vitamin D3: Promotes calcium absorption and bone health, supports muscle function, plays an important role in immune regulation and emerging evidence suggests Vitamin D deficiency may worsen neuropathic pain.

This formulation provides neuroprotective, antioxidant, and metabolic support especially in neuropathic and deficiency-related conditions.

Hybrin Plus Tablet is indicated for:

• Diabetic neuropathy and peripheral neuropathy
• Sciatica, radiculopathy, and neuralgia
• Numbness and tingling of hands and feet
• Burning feet syndrome
• Nutritional deficiencies of B-vitamins
• Chronic fatigue and general weakness
• Adjunctive therapy in neurological disorders
• Neuropathic pain associated with diabetes

• Use under medical supervision, especially in long-term therapy.
• Periodic monitoring of Vitamin B12 and folate levels is advisable.